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Weight Loss: Wegovy received FDA approval but be careful of side effects

 Weight loss: Recent FDA approval for Wegovy (semaglutide) injection on 8 March 2024 

  • Wegovy has received FDA approval for a new indication: reducing cardiovascular risk in adults with cardiovascular disease who are either obese or overweight.
  • This makes Wegovy the first weight loss medication approved to prevent life-threatening cardiovascular events in this patient population.
  • Obesity and overweight affect approximately 70% of American adults, increasing the risk of premature death and health problems like heart attacks and strokes.
  • Wegovy contains semaglutide, a GLP-1 receptor agonist. It should not be used with other semaglutide-containing products or GLP-1 receptor agonists.
  • In a large study, Wegovy significantly lowered the risk of major adverse cardiovascular events when combined with standard-of-care treatment and lifestyle counseling.


Understanding Wegovy (Semaglutide) Side Effects

Common Side Effects

  1. Nausea: Some individuals may experience nausea while taking Wegovy.
  2. Diarrhea: Diarrhea is another common side effect.
  3. Vomiting: Vomiting may occur in some cases.
  4. Constipation: Constipation can be a side effect as well.
  5. Stomach (Abdomen) Pain: Abdominal discomfort is reported by some users.

Serious Side Effects

  1. Thyroid C-Cell Tumors: In rodents, semaglutide has been associated with thyroid C-cell tumors. While the human relevance of this finding is not fully understood, Wegovy is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  2. Other Serious Effects: Although rare, some serious side effects may occur. If you experience any of the following, seek medical attention promptly:
    • Anxiety
    • Blurred vision
    • Fast heartbeat
    • Unusual tiredness or weakness
    • Slurred speech
    • Skin rash
    • Tightness in the chest
    • Trouble breathing
    • Yellow eyes or skin.

Managing Side Effects

  1. Lifestyle Adjustments:
    • Stay Hydrated: Nausea and other gastrointestinal symptoms are common side effects. Staying hydrated can help alleviate these symptoms.
    • Eat Smaller, Frequent Meals: If you experience stomach discomfort, consider eating smaller meals throughout the day. This can help prevent bloating and abdominal pain.
    • Monitor Blood Sugar Levels: Semaglutide affects blood sugar regulation. Regular monitoring, especially if you have diabetes, is crucial.
  2. Thyroid Health Monitoring:
    • Wegovy contains semaglutide, which has been associated with thyroid C-cell tumors in animal studies. While the relevance to humans is not fully understood, it’s essential to monitor your thyroid function regularly, especially if you have a history of thyroid issues.
  3. Be Aware of Serious Symptoms:
    • Although rare, serious side effects can occur. Seek medical attention promptly if you experience the below important side effects:
      • Anxiety
      • Blurred Vision
      • Fast Heartbeat
      • Unusual Tiredness or Weakness
      • Slurred Speech
      • Skin Rash
      • Tightness in the Chest
      • Trouble Breathing
      • Yellow Eyes or Skin


While Wegovy offers promising benefits for weight loss, it’s crucial to be aware of potential side effects. Always follow your doctor’s recommendations and report any unusual symptoms promptly. Remember that individual responses may vary, and what works for one person may not be the same for another. Prioritize your health and well-being as you explore treatment options.

Disclaimer: This blog post is for informational purposes only and should not replace professional medical advice. Always consult your healthcare provider before starting any new medication.

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